Publications

A new opportunity for MEMRI.

Cloyd R, Vandsburger M, Abisambra JF.

Aging. 2017; 9(8):1855-1856.

PMID:28854148

PMCID:PMC5611976

Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach.

Fontaine SN, Ingram A, Cloyd RA, Meier SE, Miller E, Lyons D, Nation GK, Mechas E, Weiss B, Lanzillotta C, Di Domenico F, Schmitt F, Powell DK, Vandsburger M, Abisambra JF.

Neurobiology of aging. 2017; 56:78-86. NIHMSID: NIHMS875761

PMID:28500878

PMCID:PMC5524451

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies.

Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.

Aging and disease. 2017; 8(3):257-266.

PMID:28580182

PMCID:PMC5440106

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.

Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B.

Cell reports. 2016; 15(7):1455-1466. NIHMSID: NIHMS780190

PMID:27160897

PMCID:PMC5325702

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis.

Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Ingram A, Fontaine SN, Mechas E, Chen J, Wolozin B, LeVine H 3rd, Zhu H, Abisambra JF.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016; 36(3):1001-7.

PubMed [journal]

PMID:26791227

PMCID:PMC4719006

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration.

Bell MC, Meier SE, Ingram AL, Abisambra JF.

Current Alzheimer research. 2016; 13(2):150-63.

PMID:26679859

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.

Bachstetter AD, Zhou Z, Rowe RK, Xing B, Goulding DS, Conley AN, Sompol P, Meier S, Abisambra JF, Lifshitz J, Watterson DM, Van Eldik LJ.

PloS one. 2016; 11(2):e0149451.

PMID:26871438

PMCID:PMC4752278

Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain.

Meier S, Bell M, Lyons DN, Ingram A, Chen J, Gensel JC, Zhu H, Nelson PT, Abisambra JF.

Journal of Alzheimer's disease : JAD. 2015; 48(3):687-702. NIHMSID: NIHMS786285

PMID:26402096

PMCID:PMC4881838

Primary age-related tauopathy (PART): a common pathology associated with human aging.

Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT.

Acta neuropathologica. 2014; 128(6):755-66. NIHMSID: NIHMS638266

PMID:25348064

PMCID:PMC4257842

Microsome Isolation from Tissue.

Bodero M, Francisco Abisambra J.

Bio-protocol. 2014; 4(3). NIHMSID: NIHMS770189

PMID:27453909

PMCID:PMC4957518

Brain injury in the context of tauopathies.

Abisambra JF, Scheff S.

Journal of Alzheimer's disease : JAD. 2014; 40(3):495-518.

PMID:24496078

Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA.

Biological psychiatry. 2013; 74(5):367-74. NIHMSID: NIHMS459469

PMID:23607970

PMCID:PMC3740016

Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.

Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013; 33(22):9498-507. NIHMSID: NIHMS486201

PMID:23719816

PMCID:PMC3733249

Imbalance of Hsp70 family variants fosters tau accumulation.

Jinwal UK, Akoury E, Abisambra JF, O'Leary JC 3rd, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013; 27(4):1450-9.

PMID:23271055

PMCID:PMC3606536

Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.

Suntharalingam A, Abisambra JF, O'Leary JC 3rd, Koren J 3rd, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA.

The Journal of biological chemistry. 2012; 287(48):40661-9.

PMID:23035116

PMCID:PMC3504779

DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA.

Journal of molecular biology. 2012; 421(4-5):653-61. NIHMSID: NIHMS357697

PMID:22343013

PMCID:PMC3371317

Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.

Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA.

The Journal of biological chemistry. 2012; 287(29):24814-20.

PMID:22674575

PMCID:PMC3397908

Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.

Abisambra JF, Jinwal UK, Jones JR, Blair LJ, Koren J 3rd, Dickey CA.

Current neuropharmacology. 2011; 9(4):623-31.

PMID:22654720

PMCID:PMC3263456

ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.

Trotter JH, Klein M, Jinwal UK, Abisambra JF, Dickey CA, Tharkur J, Masiulis I, Ding J, Locke KG, Rickman CB, Birch DG, Weeber EJ, Herz J.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(40):14413-23. NIHMSID: NIHMS329870

PubMed [journal]

PMID:21976526

PMCID:PMC3224795

The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.

Jinwal UK, Trotter JH, Abisambra JF, Koren J 3rd, Lawson LY, Vestal GD, O'Leary JC 3rd, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA.

The Journal of biological chemistry. 2011; 286(19):16976-83.

PMID:21367866

PMCID:PMC3089541

The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.

Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J 3rd, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA.

Journal of natural products. 2011; 74(1):38-44. NIHMSID: NIHMS257557

PMID:21141876

PMCID:PMC3070757

Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J 3rd, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010; 30(46):15374-82. NIHMSID: NIHMS253122

PMID:21084594

PMCID:PMC3073547

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

O'Leary JC 3rd, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J 3rd, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA.

Molecular neurodegeneration. 2010; 5:45.

PMID:21040568

PMCID:PMC2989315

Hsc70 rapidly engages tau after microtubule destabilization.

Jinwal UK, O'Leary JC 3rd, Borysov SI, Jones JR, Li Q, Koren J 3rd, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA.

The Journal of biological chemistry. 2010; 285(22):16798-805.

PMID:20308058

PMCID:PMC2878041

Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

Koren J 3rd, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA.

The Journal of biological chemistry. 2010; 285(4):2498-505.

PMID:19889640

PMCID:PMC2807306

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

Jinwal UK, Koren J 3rd, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC 3rd, Jin Y, Buchner J, Cox MB, Dickey CA.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010; 30(2):591-9. NIHMSID: NIHMS172345

PMID:20071522

PMCID:PMC2830818

LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease.

Abisambra JF, Fiorelli T, Padmanabhan J, Neame P, Wefes I, Potter H.

PloS one. 2010; 5(1):e8556.

PMID:20049331

PMCID:PMC2797391

Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases.

Jinwal UK, Koren J, O'Leary JC, Jones JR, Abisambra JF, Dickey CA.

Molecular and cellular pharmacology. 2010; 2(2):43-46. NIHMSID: NIHMS203127

PMID:20523917

PMCID:PMC2879647

Activation of the hepatic LDL receptor promoter by thyroid hormone.

Lopez D, Abisambra Socarrás JF, Bedi M, Ness GC.

Biochimica et biophysica acta. 2007; 1771(9):1216-25.

PMID:17572141

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