A new opportunity for MEMRI.

Cloyd R, Vandsburger M, Abisambra JF.

Aging. 2017; 9(8):1855-1856.



Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach.

Fontaine SN, Ingram A, Cloyd RA, Meier SE, Miller E, Lyons D, Nation GK, Mechas E, Weiss B, Lanzillotta C, Di Domenico F, Schmitt F, Powell DK, Vandsburger M, Abisambra JF.

Neurobiology of aging. 2017; 56:78-86. NIHMSID: NIHMS875761



Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies.

Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.

Aging and disease. 2017; 8(3):257-266.



Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.

Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B.

Cell reports. 2016; 15(7):1455-1466. NIHMSID: NIHMS780190



Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis.

Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Ingram A, Fontaine SN, Mechas E, Chen J, Wolozin B, LeVine H 3rd, Zhu H, Abisambra JF.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016; 36(3):1001-7.

PubMed [journal]



PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration.

Bell MC, Meier SE, Ingram AL, Abisambra JF.

Current Alzheimer research. 2016; 13(2):150-63.


MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.

Bachstetter AD, Zhou Z, Rowe RK, Xing B, Goulding DS, Conley AN, Sompol P, Meier S, Abisambra JF, Lifshitz J, Watterson DM, Van Eldik LJ.

PloS one. 2016; 11(2):e0149451.



Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain.

Meier S, Bell M, Lyons DN, Ingram A, Chen J, Gensel JC, Zhu H, Nelson PT, Abisambra JF.

Journal of Alzheimer's disease : JAD. 2015; 48(3):687-702. NIHMSID: NIHMS786285



Primary age-related tauopathy (PART): a common pathology associated with human aging.

Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT.

Acta neuropathologica. 2014; 128(6):755-66. NIHMSID: NIHMS638266



Microsome Isolation from Tissue.

Bodero M, Francisco Abisambra J.

Bio-protocol. 2014; 4(3). NIHMSID: NIHMS770189



Brain injury in the context of tauopathies.

Abisambra JF, Scheff S.

Journal of Alzheimer's disease : JAD. 2014; 40(3):495-518.


Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA.

Biological psychiatry. 2013; 74(5):367-74. NIHMSID: NIHMS459469



Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.

Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013; 33(22):9498-507. NIHMSID: NIHMS486201



Imbalance of Hsp70 family variants fosters tau accumulation.

Jinwal UK, Akoury E, Abisambra JF, O'Leary JC 3rd, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013; 27(4):1450-9.



Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.

Suntharalingam A, Abisambra JF, O'Leary JC 3rd, Koren J 3rd, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA.

The Journal of biological chemistry. 2012; 287(48):40661-9.



DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA.

Journal of molecular biology. 2012; 421(4-5):653-61. NIHMSID: NIHMS357697



Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.

Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA.

The Journal of biological chemistry. 2012; 287(29):24814-20.



Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.

Abisambra JF, Jinwal UK, Jones JR, Blair LJ, Koren J 3rd, Dickey CA.

Current neuropharmacology. 2011; 9(4):623-31.



ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.

Trotter JH, Klein M, Jinwal UK, Abisambra JF, Dickey CA, Tharkur J, Masiulis I, Ding J, Locke KG, Rickman CB, Birch DG, Weeber EJ, Herz J.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(40):14413-23. NIHMSID: NIHMS329870

PubMed [journal]



The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.

Jinwal UK, Trotter JH, Abisambra JF, Koren J 3rd, Lawson LY, Vestal GD, O'Leary JC 3rd, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA.

The Journal of biological chemistry. 2011; 286(19):16976-83.



The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.

Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J 3rd, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA.

Journal of natural products. 2011; 74(1):38-44. NIHMSID: NIHMS257557



Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J 3rd, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010; 30(46):15374-82. NIHMSID: NIHMS253122



Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

O'Leary JC 3rd, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J 3rd, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA.

Molecular neurodegeneration. 2010; 5:45.



Hsc70 rapidly engages tau after microtubule destabilization.

Jinwal UK, O'Leary JC 3rd, Borysov SI, Jones JR, Li Q, Koren J 3rd, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA.

The Journal of biological chemistry. 2010; 285(22):16798-805.



Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

Koren J 3rd, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA.

The Journal of biological chemistry. 2010; 285(4):2498-505.



The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

Jinwal UK, Koren J 3rd, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC 3rd, Jin Y, Buchner J, Cox MB, Dickey CA.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010; 30(2):591-9. NIHMSID: NIHMS172345



LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease.

Abisambra JF, Fiorelli T, Padmanabhan J, Neame P, Wefes I, Potter H.

PloS one. 2010; 5(1):e8556.



Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases.

Jinwal UK, Koren J, O'Leary JC, Jones JR, Abisambra JF, Dickey CA.

Molecular and cellular pharmacology. 2010; 2(2):43-46. NIHMSID: NIHMS203127



Activation of the hepatic LDL receptor promoter by thyroid hormone.

Lopez D, Abisambra Socarrás JF, Bedi M, Ness GC.

Biochimica et biophysica acta. 2007; 1771(9):1216-25.


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