Advancing the understanding of Alzheimer's disease and related tauopathies.
Ongoing Research Support
R01 NS091329 Abisambra (PI) 09/30/15-06/30/20
NIH/NINDS
PERK as a central mediator of neurotoxicity in tauopathies
Role: PI
Goal: Establish the impact of PERK on pathogenesis and progression of tauopathies.
R21 NS093440 Abisambra (PI) 07/15/18-05/31/21
NIH/NINDS
Elucidating the pathological consequences of tau-ribosome interactions
Role: PI
Goal: Determine the impact of tau on ribosomal function.
1 I01 BX004563-01A1 Abisambra (PI) 04/01/19-03/31/23
VA
Identification of the molecular mechanisms linking Alzheimer's disease, PERK, and mild repetitive head injury
Role: PI
Goal: Establish the role of PERK on neuronal dysfunction after closed head injury.
R56 NS110384-01 Abisambra (PI) 07/01/19-06/30/20
NIH/NINDS
Tau-mediated regulation of ribosomes in health and disease
Role: PI
Goal: Examine the impact of pathological and normal tau on ribosomal transport, function, and selectivity.
R56 AG064906 Bickford and Abisambra (mPI) 07/01/19-06/30/20
NIH/NIA
Exosomes from adipose-derived stem cells modulate age-dependent progression of tauopathies.
Role: PI
Goal: Determine the therapeutic impact of hASC-exosomes on models of tauopathy.
R61 NS115178-01 Abisambra, Borchelt, Lewis (mPI) 07/01/19-06/30/24
NIH/NINDS
Developing new conditional models to study tauopathy, amyloidosis, and their interaction
Role: mPI
Goal: Develop and characterize a new model of Alzheimer’s disease.
R01 AR066082 Esser (PI) 08/24/14-07/31/20
NIH/NIAMS
Molecular clock and skeletal muscle weakness
Role: Co-I
Goal: Determine the potential of tau spreading between neurons and muscle cells.
Completed Research Support
GRANT11811993 Abisambra (PI) 09/01/15-09/14/19
Department of Defense
The impact of PERK on post-traumatic tauopathy in Alzheimer disease
Role: PI
Goal: Establish the impact of PERK on neuronal dysfunction mechanisms of tauopathies.
Sub-Contract Del Monte (PI) 08/28/17-12/31/19
American Heart Association
Myocardial tauopathy: a new pathogenesis and treatment for heart disease
Role: co-I
Goal: Determine tau spreading between neurons and cardiomyocytes.
R01 AR066082 (supplement)Esser (PI) 08/24/14-07/31/19
NIH/NIAMS
Molecular clock and skeletal muscle weakness
Role: co-I (AD supplement)
Goal: Determine the impact of Bmal1 knockout on Alzheimer’s disease outcomes.
P30 GM110787 Abisambra (PI) 04/28/15-04/27/17
NIH/NIGMS UK-COBRE
Pilot Project: PERK inhibition for traumatic brain injury therapeutics
Role: PI
Goal: Inhibit PERK in mice after TBI as a therapeutic strategy.
NIRG-14-322441 Abisambra (PI) 02/01/15-01/13/17
Alzheimer's Association
The impact of the tau-rpS6 association in the pathogenesis of Alzheimer disease
Role: PI
Goal: Establish molecular dynamics of tau-S6 interactions.
NIRGD-12-242642 Abisambra (PI) 10/01/12-09/30/14
Alzheimer's Association
Mechanisms of tau and ER stress for novel Alzheimer’s disease therapeutics
Role: PI
Goal: Identify the pathological mechanisms linking tau and ER stress in Alzheimer’s disease.
CurePSP-6144107400 Abisambra (co-PI) 06/01/12-05/31/13
Alzheimer's Association
Mechanisms of tau and ER stress for novel PSP and CBD therapeutics
Role: co-PI
Goal: Identify the link between tau and the ER stress marker and risk factor for progressive supranuclear palsy, PERK.