Ongoing Research Support

 

R01 NS091329                                     Abisambra (PI)                                                          09/30/15-06/30/20

NIH/NINDS

PERK as a central mediator of neurotoxicity in tauopathies

Role: PI

Goal: Establish the impact of PERK on pathogenesis and progression of tauopathies.

R21 NS093440                                     Abisambra (PI)                                                          07/15/18-05/31/21

NIH/NINDS

Elucidating the pathological consequences of tau-ribosome interactions

Role: PI

Goal: Determine the impact of tau on ribosomal function.

1 I01 BX004563-01A1                          Abisambra (PI)                                                          04/01/19-03/31/23

VA

Identification of the molecular mechanisms linking Alzheimer's disease, PERK, and mild repetitive head injury

Role: PI

Goal: Establish the role of PERK on neuronal dysfunction after closed head injury.

R56 NS110384-01                               Abisambra (PI)                                                          07/01/19-06/30/20

NIH/NINDS

Tau-mediated regulation of ribosomes in health and disease

Role: PI

Goal: Examine the impact of pathological and normal tau on ribosomal transport, function, and selectivity.

R56 AG064906                                    Bickford and Abisambra (mPI)                                 07/01/19-06/30/20

NIH/NIA

Exosomes from adipose-derived stem cells modulate age-dependent progression of tauopathies.

Role: PI

Goal: Determine the therapeutic impact of hASC-exosomes on models of tauopathy.

R61 NS115178-01                               Abisambra, Borchelt, Lewis (mPI)                            07/01/19-06/30/24

NIH/NINDS

Developing new conditional models to study tauopathy, amyloidosis, and their interaction

Role: mPI

Goal: Develop and characterize a new model of Alzheimer’s disease. 

R01 AR066082                                     Esser (PI)                                                                  08/24/14-07/31/20     

NIH/NIAMS                                                                                        

Molecular clock and skeletal muscle weakness

Role: Co-I

Goal: Determine the potential of tau spreading between neurons and muscle cells.

Completed Research Support

 

GRANT11811993                        Abisambra (PI)                           09/01/15-09/14/19

Department of Defense

The impact of PERK on post-traumatic tauopathy in Alzheimer disease

Role: PI

Goal: Establish the impact of PERK on neuronal dysfunction mechanisms of tauopathies.

 

Sub-Contract                                Del Monte (PI)                            08/28/17-12/31/19

American Heart Association

Myocardial tauopathy: a new pathogenesis and treatment for heart disease

Role: co-I

Goal: Determine tau spreading between neurons and cardiomyocytes.

 

R01 AR066082 (supplement)Esser (PI)                                        08/24/14-07/31/19

NIH/NIAMS

Molecular clock and skeletal muscle weakness

Role: co-I (AD supplement)

Goal: Determine the impact of Bmal1 knockout on Alzheimer’s disease outcomes.

 

P30 GM110787                            Abisambra (PI)                           04/28/15-04/27/17

NIH/NIGMS UK-COBRE 

Pilot Project: PERK inhibition for traumatic brain injury therapeutics

Role: PI

Goal: Inhibit PERK in mice after TBI as a therapeutic strategy.

 

NIRG-14-322441                         Abisambra (PI)                           02/01/15-01/13/17       

Alzheimer's Association

The impact of the tau-rpS6 association in the pathogenesis of Alzheimer disease

Role: PI

Goal: Establish molecular dynamics of tau-S6 interactions.

 

NIRGD-12-242642                      Abisambra (PI)                           10/01/12-09/30/14       

Alzheimer's Association

Mechanisms of tau and ER stress for novel Alzheimer’s disease therapeutics

Role: PI

Goal: Identify the pathological mechanisms linking tau and ER stress in Alzheimer’s disease.

 

CurePSP-6144107400               Abisambra (co-PI)                      06/01/12-05/31/13       

Alzheimer's Association

Mechanisms of tau and ER stress for novel PSP and CBD therapeutics

Role: co-PI

Goal: Identify the link between tau and the ER stress marker and risk factor for progressive supranuclear palsy, PERK.

Funding & Support